A Five Year Review of Ovarian Cancer at a Tertiary Institution in Lagos, South-West, Nigeria

Authors

  • Kehinde Sharafadeen Okunade Department of Obstetrics and Gynaecology, College of Medicine, University of Lagos image/svg+xml Author
  • Halima Okunola Department of Obstetrics and Gynaecology, Lagos University Teaching  Hospital, Lagos, Nigeria image/svg+xml Author
  • Adeyemi A. Okunowo Department of Obstetrics and Gynaecology, College of Medicine, University of Lagos image/svg+xml Author
  • Rose Ihuoma Anorlu Department of Obstetrics and Gynaecology, College of Medicine, University of Lagos Author

DOI:

https://doi.org/10.60787/njgp.v14i2.131

Keywords:

prevalence, ovarian cancer, Lagos, Epithelial

Abstract

Background: Ovarian cancer constituted 7% of gynecological malignancies seen in Lagos, Nigeria and was the second most common cause of death among women in Lagos, Nigeria.

Objectives: The aim is to determine the prevalence of ovarian cancer and characteristics of patients with ovarian cancer at a Tertiary Institution in Lagos.

Patients and Methods: This was a retrospective review of all the patients with histologically confirmed ovarian cancer admitted to the gynecological ward of the hospital over a period of 5 years. Relevant information was extracted from the ward register and patients medical case records. Data were analyzed using Epi‑info statistical software package and results were then presented in tables and chart.

Results: Fifty cases of ovarian cancer were admitted during the period under review. This constituted 1.7% of the gynecological admission cases and 8.2% of the gynecological malignancies managed in the hospital during the study. It was the second most common gynecological malignancy. The mean age of the ovarian cancer patients was 45.7 ± 4.3 years with the majority 
of the patients (58%) being premenopausal, 34% being nulliparous and only 16% having one or more risk factors. The abdominal swelling was the most common presenting symptom with 80% of the patients presenting with advanced disease. Epithelial ovarian cancer was the most common histological variant. The most common treatment modality was surgery and chemotherapy. The patient default rate was 64%.

Conclusion: Ovarian cancer cases are on the increase. Failure of optimal management is worsened by the delay in presentation and poor compliance to treatment with high patients’ default rate.

Downloads

Download data is not yet available.

References

GLOBOCAN 2008 (IARC) Fast Stats Section of Cancer Information. Availabel from: GLOBOCAN 2008 (IARC) Fact Stats Section of Cancer Information. “http://www.iarc.fr/en/publications/pdfs-online/

wcr/2008/index.php. [Last accessed on 2013 Feb 07].

Kyari O, Nggada H, Mairiga A. Malignant tumours of female genital tract in North Eastern Nigeria. East Afr Med J 2004;81:142‑5.

Goff BA, Mandel LS, Drescher CW, Urban N, Gough S, Schurman KM, et al. Development of an ovarian cancer symptom index: Possibilities for earlier detection. Cancer 2007;109:221‑7.

Iyoke CA, Ugwu GO. Burden of gynaecological cancers in developing countries. World Obstet Gynaecol 2013;2:1‑7.

Nkyekyer K. Pattern of gynaecological cancers in Ghana. East Afr Med J 2000;77:534‑8.

Ugwu EO, Iferikigwe ES, Okeke TC, Ugwu AO, Okezie OA, Agu PU. Pattern of gynaecological cancers in University of Nigeria Teaching Hospital, Enugu, South Eastern Nigeria. Niger J Med 2011;20:266‑9.

Buhari MO, Ojo BA, Ijaiya MA, Aboyeji PA. Ovarian cancers in Ilorin, Nigeria – A review of over 80 cases. Nig Q J Hosp Med 2005;15:127‑30.

Onyiaorah IV, Anunobi CC, Banjo AA, Fatima AA, Nwankwo KC. Histopathological patterns of ovarian tumours seen in Lagos University Teaching Hospital: A ten year retrospective study. Nig Q J Hosp Med 2011;21:114‑8.

Odukogbe AA, Adebamowo CA, Ola B, Olayemi O, Oladokun A, Adewole IF, et al. Ovarian cancer in Ibadan: Characteristics and management. J Obstet Gynaecol 2004;24:294‑7.

BankheadCR, KehoeST, AustokerJ. Symptoms associated with diagnosis of ovarian cancer: A systematic review. BJOG 2005;112:857‑65.

Schindler AE. Non‑contraceptive benefits of oral hormonal contraceptives. Int J Endocrinol Metab 2013;11:41‑7.

Rabiu KA, Akinola OI, Adewunmi AA, Fabamwo AO, Adedeji MO, Popoola AO. Delays in presentation and management of ovarian cancer in Lagos, Nigeria. J Obstet Gynaecol 2013;33:305‑8.

Gharoro EP, Eirewele O. Cancer of the ovary at the University of Benin Teaching Hospital: A 10‑year review, 1992‑2001. Afr J Med Sci 2006;35:143‑7.

Gilani MM, Behnamfar F, Zamani F, Zamani N. Frequency of different types of ovarian cancer in Vali‑e‑Asr Hospital (Tehran University of Medical Sciences) 2001‑2003. Pak J Biol Sci 2007;10:3026‑8.

Dhakal HP, Pradhan M. Histological pattern of gynecological cancers. JNMA J Nepal Med Assoc 2009;48:301‑5.

Tanko MN, Kayembe MA, Cainelli F, Vento S. Malignant tumours of the genital tract among Batswana women. Ghana Med J 2012;46:142‑6.

Yakasai IA, Ugwa EA, Otubu J. Gynecological alignancies in Aminu Kano Teaching Hospital Kano: A 3 year review. Niger J Clin Pract 2013;16:63‑6.

Wong KH, Mang OW, Au KH, Law SC. Incidence, mortality, and survival trends of ovarian cancer in Hong Kong, 1997 to 2006: A population‑based study. Hong Kong Med J 2012;18:466‑74.

Monga A, Dobbs S, editors. Diseases of the ovary. In: Gynaecology by Ten Teachers. 19th ed. UK: Hodder Arnoldl; 2011. p. 110‑9.

Goff BA, Mandel L, Muntz HG, Melancon CH. Ovarian carcinoma diagnosis. Cancer 2000;89:2068‑75.

Vine MF, Ness RB, Calingaert B, Schildkraut JM, Berchuck A. Types and duration of symptoms prior to diagnosis of invasive or borderline ovarian tumor. Gynecol Oncol 2001;83:466‑71.

Vine MF, Calingaert B, Berchuck A, Schildkraut JM. Characterization of prediagnostic symptoms among primary epithelial ovarian cancer cases and controls. Gynecol Oncol 2003;90:75‑82.

Lataifeh I, Marsden DE, Robertson G, Gebski V, Hacker NF. Presenting symptoms of epithelial ovarian cancer. Aust N Z J Obstet Gynaecol 2005;45:211‑4.

Paulsen T, Kaern J, Kjaerheim K, Tropé C, Tretli S. Symptoms and referral of women with epithelial ovarian tumors. Int J Gynaecol Obstet 2005;88:31‑7.

Olsen CM, Cnossen J, Green AC, Webb PM. Comparison of symptoms and presentation of women with benign, low malignant potential and invasive ovarian tumors. Eur J Gynaecol Oncol 2007;28:376‑80.

Webb PM, Purdie DM, Grover S, Jordan S, Dick ML, Green AC. Symptoms and diagnosis of borderline, early and advanced epithelial ovarian cancer. Gynecol Oncol 2004;92:232‑9.

Eltabbakh GH, Yadav PR, Morgan A. Clinical picture of women with early stage ovarian cancer. Gynecol Oncol 1999;75:476‑9.

Chan YM, Ng TY, Lee PW, Ngan HY, Wong LC. Symptoms, coping strategies, and timing of presentations in patients with newly diagnosed ovarian cancer. Gynecol Oncol 2003;90:651‑6.

Attanucci CA, Ball HG, Zweizig SL, ChenAH. Differences in symptoms between patients with benign and malignant ovarian neoplasms. Am J Obstet Gynecol 2004;190:1435‑7.

Al-Rawahi T, Lopes AD, Bristow RE, Bryant A, Elattar A,

Chattopadhyay S, et al. Surgical cytoreduction for recurrent empirical epithelial cancer. Cochrane Database Syst Rev 2013:2:CD008765. doi: 10.1002/14651858.CD008765.pub3.

Downloads

Published

2016-12-01

Issue

Section

Original Articles

How to Cite

1.
Okunade KS, Okunola H, Okunowo AA, Anorlu RI. A Five Year Review of Ovarian Cancer at a Tertiary Institution in Lagos, South-West, Nigeria. NJGP [Internet]. 2016 Dec. 1 [cited 2025 Apr. 26];14(2):23-7. Available from: https://njgp.net.ng/index.php/home/article/view/131

Most read articles by the same author(s)

Similar Articles

21-30 of 51

You may also start an advanced similarity search for this article.